The Yee Laboratory at MD Anderson Cancer Center focuses on research to understand human T cell biology, anti-tumor immunity, and the development of translational strategies using TCR-based cellular therapies. This position will support the scientific needs of the Immunopeptidome discovery pipeline within the STRIDE Program for TCR-Based Therapeutics (ProTCT). The ultimate goal of ProTCT is to deliver novel T cell-based treatment modalities for advanced cancers, investigate T cell based-responses across the IO spectrum and contribute to MD Anderson's mission to make Cancer History.

Key Functions

• Design and perform high quality lab research through their own work or in collaboration with team members.

• Apply practical knowledge of immunology and cell-based assays including cytotoxicity, cell proliferation, and/or cytokine secretion to assess T cell functionality.

• Expertise in planning, performing, and analyzing flow cytometric assays to characterize T cell phenotype.

• Proficient in culturing and manipulation of primary immune cells and cancer cell lines.

• Possess significant knowledge of immunology and cell therapy approaches to apply to every day experimental needs.

Support and Continuity

• Participate in the design of experiments, data analysis and results interpretation.

• Aide in evaluating new and novel methods to validate immunogenic peptides presented by MHC.

• Support molecular biology studies to identify relevant anti-tumor TCRs.

• Participate in lab and team discussions on project progress, results, and future directions.

• Adopt and evaluate existing methods and tools, improve methods, establish and maintain infrastructure and analytic pipelines in the lab within the immunopeptidome focus area.

• Meets with collaborators to discuss projects and communicate results.

• Work with teams of individuals to integrate data / metadata and assist postdocs and students in the lab in analyzing and resolving analysis issues.

• Assist with manuscript and grant preparation and present results during lab meetings, at department and institutional meetings and seminars, and at appropriate scientific conferences.

• Employ safe laboratory practices and help to maintain current and accurate records of research data.

Onsite Presence: 100% onsite presence is required.

WORKING CONDITIONS

Frequency

Deadlines

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PHYSICAL DEMANDS

Frequency

Weight

Keyboarding

Sitting

Carrying

Standing

Pushing/Pulling

Reaching

Constant 67-100%

Constant 67-100%

Occasionally 11-33%

Occasionally 11-33%

Occasionally 11-33%

Seldom 3-10%

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COGNITIVE DEMANDS:

Analytical Ability

Attention to detail

Interpersonal Skills

Oral Communication

Working Alone

Written Communication

EDUCATION:

Required: Masters degree in one of the natural sciences or related field.

Preferred: PhD in one of the natural sciences or related field.

EXPERIENCE:

Required: Four years of experience in experimental or scientific work. With PhD, no experience required. With Medical degree, two years of experience in experimental or scientific work.

Preferred: At least three-year hands-on experience in cell therapy research is preferred. Proficiency in Immunology and Immunological techniques strongly preferred.

It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html

Additional Information

• Requisition ID: 167824

• Employment Status: Full-Time

• Employee Status: Regular

• Work Week: Day/Evening

• Minimum Salary: US Dollar (USD) 66,500

• Midpoint Salary: US Dollar (USD) 83,000

• Maximum Salary : US Dollar (USD) 99,500

• FLSA: exempt and not eligible for overtime pay

• Fund Type: Soft

• Work Location: Hybrid Onsite/Remote

• Pivotal Position: Yes

• Referral Bonus Available?: Yes

• Relocation Assistance Available?: Yes

• Science Jobs: Yes

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